At the Reading, England site, Dextra (alternatively known as Dextra UK) offers an effective custom synthesis service, providing novel, innovative synthetic solutions to the synthesis of carbohydrates and other complex chiral molecules on behalf of individual clients. Dextra is focused on adding value for its clients, and one such example is the Dextra science teams’ expertise in reducing the number of steps required to produce a target compound.
The team is able to produce batches scaling from a few milligrams to several kilograms, operating at temperatures from −90°C to 200°C.
Dextra’s core capabilities include:
• Route design
• Efficient multi-step synthesis
• Process development, optimisation and scale up
• Process validation
• Glycosylation reactions
• Hydrogenation, oxidation and reduction chemistry
• Conjugation chemistry
The Dextra team has considerable experience in the synthesis of sugar related active pharmaceutical ingredients (APIs), medically relevant oligosaccharides and a wide range of carbohydrates conjugated to proteins, peptides and solid support matrices, including affinity gels. In addition, Dextra possesses key manufacturing competencies in the production of chiral compounds, lactones, imino sugars, unnatural L-sugars and oligosaccharides.
Dextra provides:
• Project Management including access to highly qualified and experienced organic chemists
• An integrated approach to product/process development, with the ability to progress to larger scale and/or clinical trial material if required.
• Fully cGMP compliant process development and analytical support for the scope of the project
cGMP production facility
Dextra offers full cGMP manufacturing at its Reading facility to support phase I and phase II clinical trials in reactors up to 50 L and operating in temperatures from −90°C to 200°C. Late phase and commercial production is available at the NZP Dextra cGMP facility in New Zealand. cGMP manufacture is supported by a full analytical capability that includes method development, qualification and validation, as well as degradation and stability studies, specification development and full QC testing of all incoming raw materials and intermediates. The analytical facilities are resourced with qualified equipment which allows Quality Assurance and Control support at all phases of your projects.